TO STUDY THE EFFICACY OF COLCHICINE IN REDUCING INSTENT RESTENOSIS IN INDIAN PATIENTS WITH BARE METAL STENTS

Abstract

1. Background
Various drugs and modalities has been evaluated to address the In-stent restenosis in stents deployed for obstructive coronary artery disease. In this study we evaluated the efficacy of Colchicine in reducing Instent Restenosis in Indian patients with Bare Metal Stents in terms of binary restenosis, target lesion revascularization (TLR) and late lumen loss (LLL).
2. Methods.
The study was conducted at tertiary care hospital over a period of one year. The patients who presented with acute coronary syndrome or chronic stable angina requiring revascularization were included in the study.
3. Results
A total of 41 patients who fulfilled the inclusion criteria were randomized to two groups and followed up with a check CAG at 12 months. Out of 41 patients enrolled, 21 were randomly assigned to receive colchicine (colchicine group) and 20 to receive placebo (placebo group). The late lumen loss was calculated for each patient by subtracting the MLD at 12 months from after
procedure MLD and the mean late lumen loss in the two groups was 0.48±0.60 and 0.55±0.52 mm respectively which was not significant statistically (p=0.67).
4. Conclusion
In our study we found equivocal results in as much the efficacy of colchicine in preventing restenosis in all comers of an Indian population albeit this study confirmed the safety and compliance of colchicine in the study population.