The Therapeutic Potential of Molecular Hydrogen in Periodontitis: A Review of Oxidative Stress Modulation.

Abstract

Abstract: Periodontitis, a chronic inflammatory disease affecting the supporting structures of teeth, is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, leading to oxidative stress. This review aims to explore the therapeutic potential of molecular hydrogen (H2) in periodontitis by examining its mechanisms of action in modulating oxidative stress. We summarize current evidence regarding H2's selective antioxidant properties, its ability to reduce inflammation, and its potential applications in periodontal health. While preclinical studies suggest promising results, further clinical trials are needed to validate the efficacy of H2 as a therapeutic agent in periodontitis management.