“STUDY OF SERUM LIPID PROFILE IN TYPE 2 DIABETES MELLITUS”
DOI:
https://doi.org/10.48047/Keywords:
T2DM -Type 2 Diabetes Mellitus, LDL - Low Density Lipoprotein, HDL-High Density Lipoprotein, TG- Triglyceride, HbAIc - Glycated Hemoglobin.Abstract
Type 2 diabetes mellitus is an inherited metabolic disorder characterized by hyperglycaemia with resistance to ketosis. The onset is usually after age 40 years. Patients are variably symptomatic and frequently obese, hyperlipidaemia and hypertensive. Clinical, pathological and biochemical evidence suggests that the disease is caused by a combined defect of insulin secretion and insulin resistance. Goals in the treatment of hyperglycaemia, dyslipidaemia and hypertension should be appropriate to the patient's age, the status of diabetic complications and the safety of the regimen. Non pharmacologic management includes meal planning to achieve a suitable weight. A cross sectional study was carried out for a period of one year. Present study was aim to see the alternation in lipid profile of non insulin dependent diabetic patients and to find the significance of (Total cholesterol, HDL cholesterol, LDL cholesterol,
triglycerides) in Type 2 Diabetes patients. The patients were about 30 biochemically proven cases of type 2 diabetic patients with fasting glucose level > 126mg/dl in the age group of 25-60 years. After taking informed consent, under all aseptic precautions about 6 ml of venous blood were collected in a sterile bulb after overnight fasting. Serum were separated by centrifugation and used for analysis. Serum cholesterol, triglyceride, LDL Cholesterol levels in diabetic patients were elevated while HDL Cholesterol levels were in diabetic patients with good glycaemic control was decreased and it was further decreased in diabetic patients with poor control. Significant correlation between HbA1c and various circulating lipid parameters and significant difference of lipid parameters in two groups (≤7.0% and >7.0%) of glycated haemoglobin indicates that HbA1c can be used as a potential biomarker for predicting dyslipidaemia in type 2 diabetic patients in addition to glycaemic control hence early diagnosis can be accomplished through relatively inexpensive blood testing.
