COMPARATIVE STUDY TWO DIFFERENT DOSES OF DEXMEDETOMIDINE AS AN ADJUVANT TO INTRATHECAL HYPERBARIC BUPIVACAINE IN INFRAUMBILICAL SURGERIES

Abstract

Background: In recent years, α- adrenoreceptor agonists like dexmedomidine and clonidine gain wide popularity as anesthetic adjuvants. Their primary mechanism is sympatholytic. They reduce peripheral norepinephrine release by the stimulation of prejunctional inhibitory α- adrenoceptors. Aim: To compare the analgesic effect of two different doses of dexmedetomidine on intrathecal hyperbaric bupivacaine in infraumblical surgeries. Methods: The present study was a prospective, randomized, double blind Comparative study of two doses of Dexmedetomidine 5μg and 10μg as an adjuvant to intrathecal hyperbaric Bupivacaine in infraumbilical surgeries. Study population consisted of 90 patients divided into three groups of 30 each belonging to ASA Grade I and Grade II physical status. They received 15 mg (3ml) Bupivacaine 0.5% heavy and added 0.2 ml normal saline in group C, dexmedomidine 5μg in group D5 and dexmedomidine 10μg in group D10, total volume of 3.2 ml intrathecally.
Results: Mean time for onset of sensory in study groups was singinficantly earlier than in the control group (P < 0.001). Mean time taken to achieve highest sensory level was significantly reduced in study groups as compared to control group (P<0.001). The highest sensory dermatomal level range was T4-T8 in all groups. Overall highest sensory dermatomal level achieved was comparable in all three groups but statistically not significant (P>0.05). The Mean duration of sensory block in study groups were significantly prolonged than control group (p<0.001). Mean duration of sensory block in group D10 was also significantly prolonged than group D5. Which
was statistically highly significant (p<0.001). Time of Onset of motor blockade of study groups was significantly earlier than control group (P < 0.001). Between the study groups, onset of motor block in group D10 was significantly earlier than group D5 (P < 0.001). Mean duration of motor block in study groups were significantly prolonged as compared to in control groups (P <0.001).
Mean duration of motor block was statistically highly significant (P <0.001).