Histopathology of Intraepithelial and Invasive Penile Squamous Cell Carcinomas, and its Prognostic Significance

Abstract

Background: Penile cancers are one of the dangerous, aggressive and mutilating cancers, of which squamous cell carcinoma is the
common malignancy. Penile SCC is an unacknowledged disease and has a limited burden on urban and rural populations in the
Indian subcontinent, hence requires a better understanding. Objectives of the study: Histomorphology of variants in intraepithelial and penile invasive squamous cell carcinomas Prognostic index and outcome of the patients Methods: The case and specimen details were collected from department archives between July 2012 to June 2017. After fixation in 10% formalin, specimens have been studied. Representative areas were sampled, and sections obtained, and Statistical analysis: The Chi-square test and the Fischer exact test have been used to evaluate the associations between variables.
Results: Out of the 55 study cases, 49 (89%) cases were diagnosed as penile squamous cell carcinoma (PSCC) and 6 (11%) cases
were diagnosed as a penile intraepithelial lesion (PeIN). Most common location was over glans (24 cases), followed by foreskin
mucosal surface (15 cases). The majority of cases were classified as usual squamous cell carcinoma (33 cases) followed by verrucous carcinoma (7 cases), warty carcinoma (4 cases), Sarcomatoid variant (2 cases), one case each of pseudoglandular variant, basaloid variant and mixed carcinoma of usual with basaloid variant.
Conclusion: Routine histomorphology is useful in diagnosis of several variants of PSCC, which can be confirmed byp16 and the
prognostic index provides a better perspective of the patients condition