REPEATED DOSE ORAL TOXICITY STUDY OF ETHANOLIC EXTRACT OF OF SOLANUM TORVUM IN RATS USING - OECD 407 GUIDELINES.

Abstract

various parts of Solanum torvum (Solanaceae)extracts have has diverse ethno medicinal uses like analgesic, anti-inflammatory, angiotensin and serotonin receptor blocking activities, antidiabetic, anti-dote and for the treatment of fever, antifungal activity, antihypertensive, antioxidant, antibacterial, antiulcer, antiviral, arterial hypertension, cardio protective, erythropoietic, immunomodulatory, jaundice, leucorrhoea, malaria, metabolic correction activity, nephroprotective, wounds, tooth decay and reproductive problems. Despite its potential therapeutic uses, the toxicity profile of Solanum torvum has not been evaluated. This study assessed the subacute toxicity effects of whole plants of Solanum torvum ethanolic extract (SOE). The sub-acute toxic effect of the SOE (1000 mg/kg) was investigated by administration for 28 consecutive days as per the OECD 407 guideline. The weekly body weights were recorded. The animals were euthanized on the 29th day, and blood samples were obtained for the hematological and
biochemical investigations. The heart and liver were subjected for histological examinations.