Approach To Combat Multidrug Resistance Urinary Tract Infections: Evaluating Alternative Therapies Amidst Limited Antibiotic Options

Abstract

Introduction – Urinary tract infection (UTI) is the significant public health concern, affecting millions world 
wide and leading to substantial prescription. The primary pathogen responsible for UTI is Escherichia coli 
(E. coli) which accounts for nearly 70% cases1. Irrational use of antibiotics leads to emergence of multidrug 
resistance which poses a challenge to clinicians especially regarding the carbapenems group of antibiotics. 
With few new antibiotics expected in the next five to ten years, we need to use current antibiotics wisely 
and reconsider older ones like nitrofurantoin and Fosfomycin to combat resistance.