A STUDY TO ESTABLISH AND VALIDATE DILUTION PROTOCOL FOR HIGH SERUM PROLACTIN LEVELS: A PILOT STUDY

Abstract

Hyperprolactinemia is a prevalent endocrine disorder affecting the hypothalamic-pituitary axis. Immunological assays can yield false-low results in hyperprolactinemia due to the high dose hook effect. To counteract this, dilutions are often employed, but potential errors introduced by this process necessitate a thorough validation of the dilution protocol to ensure result accuracy. This study aimed to compare serum prolactin levels in patients with suspected hyperprolactinemia with and without dilution