To Investigate the Thyroid Function Profile in Individuals with Chronic Liver Illness and Determine its Association with the Child-Pugh Score

Abstract

Background: The relationship between thyroid hormones and liver function is intricate and may be seen in both healthy and diseased states. The liver, in conjunction with the thyroid gland, has a crucial function in the conversion of inactive Thyroxine (T4) into active Triiodothyronine (T3). In cirrhosis of the liver, the most often seen thyroid hormone profile is characterized by low levels of total T3 and free T3. This is primarily due to decreased activity of deiodinase type 1 and an increased conversion to reverse Triiodothyronine (rT3). The aim is to investigate the thyroid function profile in individuals with chronic liver illness and determine its association with the Child-Pugh score.