Doxorubicin-Loaded Aptamer S3-Linked DNA Tetrahedrons for Targeted Therapy of Nasopharyngeal Carcinom.

Authors

  • Dr. Sujeet Kumar Author

DOI:

https://doi.org/10.48047/

Keywords:

Nasopharyngeal carcinoma, Aptamer S3, CD109, 5-8F cells, DNA tetrahedrons, Doxorubicin.

Abstract

Objective: Our research group previously identified CD109 as the target of aptamer S3 in 
nasopharyngeal carcinoma (NPC). This study aimed to develop a targeted delivery system by 
conjugating aptamer S3 to DNA tetrahedrons (DTs) loaded with doxorubicin (Dox), and to 
evaluate the potential of S3-DT-Dox for targeted NPC therapy.

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Published

2013-08-10