A Comparative Acute Toxicity Study of Two Widely Used Medicinal Plants: Ocimum canum and Platycladus orientalis Leaf Extracts

Abstract

The evaluation of acute toxicity is a fundamental step in determining the safety profile of 
medicinal plants used in traditional medicine. This study compares the acute oral toxicity of 
hydroalcoholic leaf extracts of Ocimum canum (OC) and Platycladus orientalis (PO), two 
plants known for their antimicrobial, antioxidant, and anti-inflammatory properties. Using 
Wistar rats as the animal model and following OECD guidelines (425), the extracts were 
administered in increasing doses