A Multidisciplinary Study on the Pathophysiological and Molecular Link between Psoriasis and Psoriatic Arthritis: Dermatological and Orthopedic Perspective

Authors

  • Dr. Shefali Singhal, Dr. Neelesh Damani Author

DOI:

https://doi.org/10.48047/

Keywords:

Psoriasis, Psoriatic Arthritis, IL-17, IL-23, TNF-α, HLA-Cw6, HLA-B27, Nail Psoriasis, Skin–Joint Transition, Biomarkers, Systemic Inflammation.

Abstract

Psoriasis and psoriatic arthritis (PsA) are two inflammatory autoimmune diseases with significant 
genetic basis that share some clinical and pathological features but have different manifestations. 
This research paper is a multidisciplinary study examining skin joint interaction at 
pathophysiological and molecular levels concerning the IL-23/IL-17 axis, genetic biomarkers 
HLA-Cw6 and HLA- B27 along with cytokines such as TNF-α.

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Published

2018-12-25

Issue

Vol. 9 No. 4 (2018): volume 9 issue 4 (2018)

Section

Articles