Investigating the Relationship Between MicroRNA Expression Profiles and Left Ventricular Remodeling in Patients with Heart Failure

Abstract

Heart failure (HF) is a complex clinical syndrome characterized by structural and functional alterations in the heart, often leading to left ventricular (LV) remodeling. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and have emerged as key players in cardiovascular pathophysiology. This study aimed to investigate the relationship between miRNA expression profiles and LV remodeling in patients with HF. We analyzed miRNA expression in plasma samples from 120 HF patients and 60 healthy controls using next-generation sequencing (NGS) and quantitative PCR (qPCR). LV remodeling was assessed using echocardiography, and patients were stratified based on LV ejection fraction (LVEF) and LV end-diastolic volume (LVEDV). Our results revealed distinct miRNA expression patterns associated with LV remodeling, with miR-21, miR-29, and miR-133a showing significant dysregulation. These miRNAs were correlated with markers of fibrosis, hypertrophy, and inflammation. The findings suggest that specific miRNAs may be biomarkers for LV remodeling and potential therapeutic targets in HF. This study provides new insights into the molecular mechanisms underlying LV remodeling and highlights the potential of miRNA-based diagnostics and therapeutics in HF management