To study the association between serum saturated fatty acids and mortality in dialysis Patients Attending Tertiary Care Hospital, South India

Abstract

Background: Elevated serum saturated fatty acids (SFAs) have been linked to inflammation and cardiovascular risk in patients with chronic kidney disease (CKD). However, their association with mortality in dialysis patients remains unclear. Objective: To evaluate the relationship between serum SFA content and mortality in patients undergoing haemodialysis (HD) and peritoneal dialysis (PD). Methods: Hospital based cross-sectional study conducted on 50 end-stage renal disease (ESRD) patients, divided equally into HD (n=25) and PD (n=25) groups. Serum levels of 21 SFAs were measured using gas chromatography-mass spectrometry (GC-MS). Inflammatory markers, including high-sensitivity C reactive protein (CRP), were analyzed. Dietary intake was assessed via a food frequency questionnaire (FFQ-6). Survival analyses were performed using Kaplan-Meier curves and Cox proportional hazards models.