Molecular Pathology in Gastric Cancer: Implications for Surgical Treatment
DOI:
https://doi.org/10.48047/Keywords:
Gastric Cancer, Molecular pathology, HER2, Microsatellite instability (MSI), CDH1 mutations, surgical treatment, total gastrectomy, precision medicine, targeted therapies, bio-markers-driven surgery, personalized treatment, patient stratification.Abstract
Gastric Cancer is one of the major causes of death due to cancer related deaths with the main
surgical treatment being the primary management approach. Due to the application of modern
molecular pathological features, understanding of GC has improved remarkably consequently
leading to better management of the disease. Some of the key molecular markers that are include
HER2, microsatellite instability or MSI and CDH1 mutations. It was also established that these
markers help identify between total or partial gastrectomy as to which type of surgical method
should be adopted. The paper is thus about the review of the uses that molecular profiling for
gastric cancer, in particular in setting up the surgical intervention and stratifying the patient. It
focuses on how and where medicines, precision medicines, and AI can affect the innovations on
the surgical practice.
