EFFECTIVENESS OF MIFEPRISTONE AND MISOPROSTOL AV/S MISOPROSTOL ALONE IN INDUCTION OF LABOUR – A RANDOMIZED CONTROLLED TRAIL

Abstract

In order to determine whether the combination of mifepristone and misoprostol is more effective than misoprostol alone in causing labour to begin in women who have had intrauterine foetal demise. The study was a parallel group superiority trial that was randomized, double-blind, and placebocontrolled. Oral administration of 200 mg of mifepristone or matching placebo tablets was given to 110 pregnant women who had previously suffered foetal mortality occurring at or after 20 weeks of
gestation, according to a computer-generated random number sequence. Women in both groups were given misoprostol vaginally 36 to 48 hours later. The primary outcomes that were examined were the induction-delivery interval and the fetal-placental delivery rate within 24 hours of starting the first dosage of misoprostol without any further interventions. The success rate of a woman's birth was significantly higher in the group that got mifepristone in addition to misoprostol (71.2%) than in the group that received just misoprostol (71.2%). When misoprostol was used in conjunction with mifepristone, the average induction-delivery interval was 9.8 hours with a standard deviation of 4.4, compared to 16.3 hours with a standard variation of 5.7, and the difference was statistically significant (P < 0.001). When compared to using misoprostol alone, a combination of mifepristone and misoprostol greatly increased the success rate of deliveries and decreased the time between
induction and delivery for women who had suffered foetal death.