Genetic testing for channelopathies, more than ten years progress and remaining challenges

Abstract

 Cardiac channelopathy, or primary cardiac electrical disease indicates myocyte ion channel dysfunction due to encoding ion channel gene and related gene mutation. Channelopathy usually causes the unstable cardiac electrical activity and results in arrhythmia. Brugada syndrome, long QT syndrome and short QT syndrome are three paradigms of congenital cardiac channelopathies in which a single gene mutation causes clinical arrhythmia, syncope and sudden cardiac death (SCD).