CORRELATION OF SERUM HOMOCYSTEINE, URIC ACID AND C REACTIVE PROTEIN LEVEL IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Abstract

Introduction: The term "acute myocardial infarction" (AMI) describes the destruction of heart muscle tissue brought on by ischemia, or the lack of oxygen to the heart's tissue. Aim: To investigate the correlation between
serum levels of homocysteine, uric acid, and C-reactive protein in patients diagnosed with acute myocardial
infarction (AMI). Methods: A total of 60 patients with AMI were enrolled in this study. After recruitment, detailed
history was recorded and physical examination of subjects was carried out. A serum sample, used to determine the
homocysteine, uric acid concentrations and other general biochemical assays, was obtained with one anticoagulantfree 7.5 mL test tube. Other biochemical assays were performed and CRP (mg/L) was measured. Subjects were
grouped according to Killip classification. Results: In present study, mean Homocysteine (umol/l) in Killip class I
was 4.86±2.01, in class II was 5.97±2.30, in class III was 8.44±4.73 and in class IV was 13.47±6.12 (p <0.01). Mean
uric acid (mg/dl) in Killip class I was 2.13±1.81, in class II was 2.54±1.74, in class III was 3.65±1.11 and in class IV
was 4.51±1.07 (p <0.01). Mean C-Reactive Protein (mg/l) in Killip class I was 0.72±0.57, in class II was 1.61±0.88,
in class III was 5.96±3.03 and in class IV was 8.75±4.84, (p value <0.01). A statistically significant correlation was
found between Homocysteine & Uric acid level with Coefficient of correlation being 0.58 ( p value <0.01) ; between
Homocysteine & C-Reactive Protein level with Coefficient of correlation being 0.43 (p=0.002) ; between Uric acid
& C-Reactive Protein level with Coefficient of correlation being 0.41 (p value=0.005). Conclusion:The study found
a significant correlation between blood levels of C-Reactive Protein (CRP), Uric acid, and Homocysteine with Killip
classification in patients with Acute Myocardial Infarction. As the Killip classification stages progressed, the levels
of these biomarkers also increased. There was a positive and statistically significant correlation between
Homocysteine and Uric acid levels, Homocysteine and CRP levels, as well as Uric acid and CRP levels. These
findings suggest that since these biomarkers are involved in Myocardial Infarction, monitoring their serum levels
together could be beneficial for evaluating and managing these patients.