Study of Serum Alkaline Phosphatase in Different Histological Grades of Head and Neck Squamous Cell Carcinoma

Abstract

Cancer or Neoplasm is a disease in which abnormal cell divide uncontrollably and can be an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the same excessive manner after cessation of the stimuli which evoked the change. Recently many studies have suggested a prognostic role of serum alkaline phosphatase in carcinoma of head and neck. This study was conducted to find the levels of serum alkaline phosphtase in different histological grades of head and neck squamous cell carcinoma. It was a cross sectional study. A total of 85 clinically established patients, of local carcinoma of head and neck were taken for the study. Cases included all patients between age 18 to 70 years having locally squamous cell carcinoma of head and neck region and have not received any prior treatment for malignancy. There was a statistic significant increase in serum alkaline phosphtase level in poorly differentiated squamous cell carcinoma as compared to well differentiated squamous cell carcinoma.