C-reactive protein: Unveiling its reliability as a sepsis biomarker

Abstract

Background: The term “sepsis” is primarily used to distinguish between a microbiologically-based sickness and a similar clinical state that can occur in a number of non-microbial disorders. Traditionally blood cultures are used to aid in the diagnosis of patients with suspected sepsis secondary to either a fungemia or bacteremia. But accurate microbiological identification may be delayed due to the lengthy nature of conventional standard culture techniques. C reactive protein which is an acute phase protein synthesized by liver as an immunological response to any inflammation, injury or infection. Its level in blood may be regularly checked and used as a marker for the improvement or worse of inflammation and infection.