Evaluating the Susceptibility Profile of Levonadifloxacin against MRSA and Fluoroquinolone-Resistant Staphylococcus Isolates in contrast to other prescribed antibiotics

Abstract

Introduction: According to the World Health Organization, the likelihood of mortality due to MRSA infections is estimated to be 64% higher compared to that caused by susceptible Staphylococcal isolates. In India, the prevalence of MRSA is considerable and varies across regions. Western India has reported a 25% MRSA prevalence, while Southern India has reported a higher rate of 50%.
Aims & Objectives: To find out the invitro susceptibility pattern of MRSA and the susceptibility of fluoroquinolone-resistant Staphylococcal isolates (including MRSA) against Levonadifloxacin along with other antibiotics within formulary.
Material & Methods: This was a prospective, descriptive study carried out in the Department of Microbiology, Central Laboratory School of Medical Science and Research (SMS&R), Sharda Hospital, Sharda University Greater Noida. For in-vitro susceptibility of MRSA, isolates positive for catalase and coagulase test (Staphylococcus aureus) were subjected for Antibiotic sensitivity testing along with cefoxitin disc and results were interpreted according to CLSI guidelines. Results: In the present study Gram positive isolates were found to be highly sensitive for Vancomycin (100%) followed by Linezolid (98%), Teicoplanin (92.8%), nitrofurantoin (83.14%) and Fosfomycin (88.37%) whereas, Cefipime was the least sensitive (1.2%) drug among all the antibiotics tested. MRSA was found to be highly sensitive for Vancomycin (100%) followed by Linezolid (96.8%), Teicoplanin (96.8%), Levonadiflocxacin (89.1%) and Gentamicin (67.4%) whereas, Cefoxitin was the least sensitive (0%) drug among all the antibiotics tested.
Conclusion: As the antibiotic resistance is on the rise nowadays, updating the strategies to overcome the growing antibiotic resistance like selection of narrow spectrum antibiotics with low resistance properties and antibiotic resistance surveillance is need of the hour.