SCREENING OF ANTITHROMBOTIC EFFECT OF ETHANOLIC EXTRACT OF BRAHMI (BACOPA MONNIERA) IN MICE

Abstract

Natural substances are served as the source of traditional and the modern drugs. Most of these entities are derived from the higher plants. The antioxidant plants that have clinically documented to be effective in thrombosis. Bacopa monniera is a small creeper, commonly known as brahmi or jalanimba is well documented as antioxidant herb. Therefore for it appears worthy to investigate the effect of ethanolic extract of bacopa monniera (10mg, 20mg& 30 mg kg-1 , i.p.) on thrombosis in mice, using bleeding time methods, all the agents were administered on each day and repeated for 5 & 29 consecutive days and on
6 th & 30th day, 30 min before the determination of bleeding time & λmax. The Brahmi extract significantly decreased the bleeding time and λmax as compared to vehicle (normal saline & distilled water) treated control groups. The results suggests that ethanolic extract of bacopa monniera (Brahmi) is a promising antithrombotic plant based agent. The antithrombotic effect of brahmi may be due to its antioxidant property, because oxidants play a significant role in hypercoagulation of blood.