A Study On Lipid Profiles In Chronic Liver Diseases
DOI:
https://doi.org/10.48047/Keywords:
Chronic liver disease, cirrhosis, lipid profile, total cholesterol, triglycerides, HDL-C, LDL-C.Abstract
Background: Chronic liver diseases, including cirrhosis, are often associated with alterations in
lipid metabolism. This study aimed to evaluate the lipid profiles of patients with cirrhosis and
compare them to healthy individuals.
Methods: This case-control study included 25 patients with diagnosed cirrhosis (case group) and 25 age- and sex-matched healthy individuals (control group). Fasting lipid profiles, including total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured in both groups using standard
laboratory techniques. Differences in lipid parameters between the two groups were analyzed using appropriate statistical tests.
Results: Patients with cirrhosis exhibited significantly lower levels of total cholesterol (135 ± 30
mg/dL vs. 180 ± 25 mg/dL, p < 0.001) and LDL-C (70 ± 25 mg/dL vs. 110 ± 20 mg/dL, p < 0.001) compared to the healthy controls. HDL-C levels were also decreased in the cirrhosis group
(30 ± 10 mg/dL vs. 45 ± 12 mg/dL, p < 0.001). However, triglyceride levels were significantly higher in patients with cirrhosis (180 ± 80 mg/dL vs. 120 ± 50 mg/dL, p < 0.001).
Conclusions: Patients with cirrhosis exhibited a distinct lipid profile characterized by decreased levels of total cholesterol, LDL-C, and HDL-C, along with elevated triglyceride levels compared to healthy individuals. These alterations in lipid metabolism may contribute to the pathogenesis and complications associated with chronic liver diseases. Further research is warranted to explore the underlying mechanisms and potential therapeutic implications of these findings.
