Intubating dose of rocuronium and cisatracurium in adults undergoing elective surgeries under general anesthesia: Comparison of intubation score

Abstract

The volume of distribution of cisatracurium is limited by its large molecular weight and high polarity. The steady state volume of distribution is equal to 145 ml/kg in healthy adults receiving opioid anaesthesia which is approximately 21% larger in similar patients receiving inhalation anaesthesia. Rocuronium acts by combining with nAchRs without causing any activation of these ion receptor channels. It acts competitively with ACh at α subunits of postjunctional nAChRs. After taking written informed consent, 90 patients aged between 20 to 60 years belonging to ASA grade I and ASA grade II of either sex, undergoing elective surgery under general anaesthesia were included in the study. They were randomly divided into 3 groups of 30 patients each, who received one of the muscle relaxant for intubation. Intubation score was comparable across all three groups with p=0.248.