Comparison of heart rate between melatonin and pregabalin groups: Laryngoscopy and intubation in general anaesthesia

Abstract

Laryngoscopy and endotracheal intubation (LETI) are both regarded powerful stressors that cause haemodynamic instability, resulting in a rise in heart rate and blood pressure. A total of 50 patients planned for general anesthesia admitted in various surgical departments were included in the study after a written informed consent. In our study, we observed that HR was lower than baseline in Melatonin group compared to Pregabalin group at all-time points. The highest increase in HR in the Pregabalin group occurred at 0 minutes after intubation and recovered to baseline after 10 minutes. The difference in heart rate between the two groups was statistically significant until 10 minutes after intubation (p-0.05).