Comparison of the effect of melatonin versus pregabalin in attenuation of blood pressure responses to laryngoscopy and intubation in general anaesthesia

Abstract

Pregabalin shares structural similarities with the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), but not functionally. It operates on the central nervous system by inhibiting the production of the neurotransmitter glutamate, and it has analgesic, anticonvulsant, and anxiolytic properties. Melatonin has a wide range of actions, many of which must be attributed to changes in the CNS. In the periphery, however, there are multiple melatonin target sites. A receptor is not required for any endogenous freeradical scavenging function. Fifty normotensive patients of status ASA grade 1 and 2 between age 20-45 years old, 40-65 kg body weight, undergoing elective surgeries under general anaesthesia were included
in the study after ethical clearance. On the day of operation, the patient was evaluated preoperatively. After taking written and informed consent, indication for surgery, baseline heart rate and blood pressure were noted. Basic appropriate investigations like Hb, complete blood count, serum urea and creatinine, blood sugar, urine examination, chest X-ray and ECG were done. Comparison between systolic blood pressure at all time show statistically significant difference (p< 0.05) between the two study groups. Comparison between diastolic blood pressure at all time show statistically significant difference (p< 0.05) between the two study groups.