Study Of Cardiac Troponin T Level In Subjects With Acute Coronary Syndrome And Its Correlation With Left Ventricular Dysfunction Admitted In Tertiary Care Hospital Mysore
DOI:
https://doi.org/10.48047/Keywords:
.Abstract
Background
Acute coronary syndrome is defined as presence of acute myocardial injury detected by abnormal cardiac biomarker values in setting of signs of ischemia. Certain protein referred to as cardiac biomarkers are released from necrotic heart muscle after MI.Major predictor of long term survival after recovery from acute MI is the functional status of the left ventricle, it is described in terms of ejection fraction . Cardiac troponin T is a very reliable biomarker for detection of myocardial damage and left ventricular ejection fraction.Therefore the
present study plans to analyse the relationship between peak troponin T level after ACS and left ventriculardysfunction determined by 2d echocardiography
Objectives
1.To assess cardiac troponin t levels in patients of acute coronary syndrome and to correlate cardiac troponin t level with left ventricular ejection fraction as assessed by echocardiography after first acute myocardialinfarction.
Method Of Study
This cross sectional study included 80 patients with first attack of Acute myocardial infarction were selected and observed. Troponin T levels are measured 12 to 48 hoursafter admission so as to obtain its peak value. Two dimensional Echocardiography was also done and ejection fraction was measured. The relationship between left ventricular ejection fraction and troponinT concentration was studied using spearman’s correlation Coefficient.
Observation And Results
There was a strong negative correlation between the left ventricular ejection fraction and Troponin T
levels.Pearsons correlation coeffecient was –0.838 with p<0.0001.Troponin T value of 2.64ng/ml predicted LV Ejection fraction of <40% with high sensitivity(97.30%) and specificity(93.02%).
Conclusion
Troponin T shows a strong negative correlation with left ventricular ejection after a first episode of myocardial infarction. Its measurement is a quick, cheap, sensitive andhighly specific method in identifying cardiac injury and to determine low ejection fraction <40 percent which is associated with complications.
