Journal of Cardiovascular Disease Research
“TO STUDY THE MOLECULAR CHARACTERIZATION OF X-RAY CROSS COMPLEMENTING GROUP 1 (XRCC1) GENE AND ITS ASSOCIATED RISK FACTORS IN SENILE CATARACT PATIENTS”
Harsha M Ghanti, Saiqa R Shah, Shubham Kumar Singh, Nashra Afaq, Mukesh Kumar Patwa, Pavan Kumar Sharma
JCDR. 2024: 1291-1311
Abstract
Introduction: Cataracts are caused by the ageing of the crystalline lens of the eye, which prevents clear vision. X-ray cross-complementing group 1 (XRCC1), a DNA repair protein involved in single-strand breaks (SSBs) and BER pathway, has been reported to be responsible for the efficient repair of DNA damage caused by active oxygen, ionization, and alkylating agents is mainly responsible for cataract in patients.
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