Abstract

Diabetes mellitus is a metabolic disease involving inappropriately elevated blood glucose levels. Diabetes mellitus causes both macro and micro vesicular complications. Microalbuminuria is the earliest sign of diabetes nephropathy and carotid intima-media thickness (IMT) of Common carotid artery gives an estimate of early lesion of atherosclerosis. Elevated serum uric acid is an risk predictor for cardiovascular and kidney diseases. Materials and Methods: The present study comprised of 130 type II diabetes mellitus patients of both genders. All were informed regarding the study and their written consent was obtained. Data such as name, age, gender etc. was recorded. In all, uric acid (UA) was measured by enzymatic photometric test, urine albumin was measured by immunoturbidimetric assay, urine creatinine was measured using creatinine Jaffe method and albumin creatinine ratio (ACR) was calculated by dividing urine albumin concentration with urine creatinine concentration. Common carotid artery and internal carotid artery intima-media thickness (in centimetres) of both sides was recorded. Results: Out of 130 patients, males were 70 and females were 60. Mean uric acid in males was 6.81 mg/dl and in females was 5.15 mg/dl. Albumin showed normoalbuminuria in 60, micromoalbuminuria in 40 and macromoalbuminuria in 30. IMT was between 0.4-0.5 cm in 24, 0.5- 0.6 cm in 28, 0.6-0.7 cm in 40 and 0.7-0.8 cm in 18 subjects. The difference was significant (P< 0.05). UA had positive correlation with logarithm of urine albumin excretion and IMT (P< 0.05) Conclusion: In this study, we have found that asymptomatic hyperuricemia is highly prevalent in type 2 Diabetes mellitus patients. Serum UA concentration serves as early and independent marker of renal dysfunction in type 2 Diabetes mellitus patients. Serum UA concentration serves as early marker of carotid atherosclerosis in type 2 Diabetes mellitus patients.

Description