Abstract

ABSTRACT Background: Chronic Kidney Disease (CKD) is a progressive condition characterized by a decline in glomerular filtration rate (GFR) and is frequently accompanied by comorbidities such as hypertension and diabetes. Gastrointestinal (GI) complications are common in CKD patients, often exacerbating their clinical burden. Helicobacter pylori infection is known to contribute to GI tract inflammation and ulceration, yet its prevalence and impact on CKD patients remain underexplored. This study aims to investigate the prevalence of H. pylori infection and assess upper GI abnormalities in CKD patients, particularly in relation to disease stage. Objective: This study aimed to investigate the prevalence of Helicobacter pylori infection and assess upper gastrointestinal (GI) abnormalities in patients with Chronic Kidney Disease (CKD), focusing on their correlation with CKD stages. Methods: A cross-sectional study was conducted involving 52 CKD patients aged over 18 years. Participants were selected based on specific inclusion and exclusion criteria, excluding those with severe comorbidities and certain lifestyle factors. Data collection included demographic information, clinical history, and laboratory investigations. Upper GI endoscopy was performed to identify abnormalities, and Helicobacter pylori infection was detected using the Rapid Urease Test (RUT). Statistical analysis was conducted to explore associations between CKD stages, GI abnormalities, and H. pylori infection.

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