Abstract

Background: Adiponectin levels are decreased in patients with metabolic syndrome (MetS). Thus, adiponectin can be a useful indicator for early diagnosis of metabolic syndrome. There are few studies from India using adiponectin as a marker of MetS. Objective: To study the correlation of adiponectin with other markers of metabolic syndrome. Methods: Hospital based, case control study was carried out among 80 cases (having MetS) and 80 healthy controls. Detailed history, clinical examination, anthropometry was carried out. Fasting blood sugar and lipid profile was estimated by enzymatic methods. Low density lipoprotein cholesterol was calculated by using Friedewald formula and Serum Adiponectin was assayed by ELISA kit. Results: Cases and controls were similar for age and sex. Mean body mass index (BMI), waist circumference (WC), weight, fasting blood sugar (FBS), total cholesterol, serum triglycerides (TG), were significantly higher in cases compared to controls (p<0.05). Serum HDL and serum adiponectin were significantly lower in cases compared to controls (p<0.05). Serum adiponectin was significantly correlated with all components of MetS (p<0.05). It was negatively correlated with WC, FBS, TG, whereas it was positively correlated with HDL. Serum adiponectin level was significantly higher among the normal weight individuals compared to the overweight and obese individuals (p<0.05). Conclusion: Hypoadiponectinemia is closely associated with the clinical phenotype of the metabolic syndrome and measuring the plasma concentration of adiponectin may be useful for the diagnosis of the metabolic syndrome. Key words: Adiponectin, correlation, metabolic syndrome, lipid profile

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