Abstract

Introduction: There is increasing incidence of endometrial carcinoma in developing countries, with it being the second most common malignancy of the female genital tract. The Bcl-2 gene is an important component of the Bcl-2 family of proteins which play a central role in regulating cell death. Ki 67 is widely used as a cell proliferation marker to grade tumours. The objective of this study to understand the correlation between Bcl-2 and Ki-67 expression and the clinical stages of endometrioid endometrial carcinoma Materials and Methods : A retrospective analysis was conducted on 20 endometrial carcinoma cases. Immunohistochemical staining of Bcl-2 and Ki-67 was performed and expression levels were scored. The expression levels were evaluated and correlated with tumor staging according to the TNM staging. Results : 10 cases were of stage 1, 08 cases were of stage 3 and only 2 cases belonged to stage 2. All cases were 100% positive for both Bcl-2 and Ki 67 staining.

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