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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    EFFECT OF MIFEPRISTONE ON UTERINE FIBROIDS- COMPARATIVE STUDY


    Ramya V A (1) MBBS ; Vasantha Kumari MBBS, DGO(obs&gyn), MD ; Rajapriya V MBBS
    JCDR. 2024: 1588 -1596

    Abstract

    INTRODUCTION : Mifepristone (RU 486) is a progesterone receptor modulator with antagonistic properties. It binds strongly to endometrial progesterone receptors, minimally to estrogen receptors, and upregulates androgen receptors. In a placebo-controlled trial low dose mifepristone (RU 486) has been shown to decrease myoma size as well as symptoms. An increase in androgen receptors also contributes to antiproliferative effects. Mifepristone also delays or inhibits ovulation, which may produce amenorrhoea. Direct suppressive effects on endometrial vasculature as well as on reducing stromal vascular endothelial growth factor (VEGF) have also been suggested for reducing menstrual blood loss.

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    Volume 15 Issue 11

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