Abstract

Background: Recently, research has been conducted on proteins such as lipocalin-2 (LNC2) and peptides that play roles in regulating metabolism, and also research has been conducted on the level of lipids and lipoproteins such as [cholesterol and triglycerides, LDL ,VLDL] which can be considered as potential markers of insulin resistance in some patients. Medical conditions, such as diabetes, obesity, and polycystic ovary syndrome (PCOS). gained in interest. Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with hyperandrogenemia and anovulatory failure, which is often accompanied by metabolic disorders, including obesity, dyslipidemia, hyperinsulinemia, and insulin resistance. Methods: Venous blood samples (5 ml) were collected from 200 women representing two groups. The first group consisted of 150 blood samples from women with polycystic ovary syndrome, the second group, 50 samples from healthy women. Lipocalin-2 protein concentration was measured using ELISA, lipids and lipoprotein levels were measured by spectrophotometer, and its gene expression was measured by quantitative real-time PCR (qRT-PCR).

Description

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