Abstract

Background It is estimated that there are around 3 million deaths annually due to COPD worldwide. According to WHO COPD is 3rd leading causes of death worldwide. COPD is characterized by progressive destruction of the pulmonary parenchyma frequently. The result of response to external stimuli (i.e long term exposure of cigarette smoking, environmental pollution) which culminates the progressive airway limitation. Inflammation in COPD may play a role via various cell type like neutrophil ,macrophages and lymphocyte. In this regard scientist have devoted their attention to the ratio of some of inflammatory markers as for examples, neutrophil to lymphocyte Ratio and platelet to lymphocyte ratio to know the role in systemic inflammation. METHOD : This prospective observational study was conducted in 50 individual who were either admitted or visited as an out-patient basis in medical ward of Guru Nanak Dev Hospital, attached with Government Medical College, Amritsar, with acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD) during the 1 year study period (1ST January 2023 to 31ST December 2023). Patients with acute exacerbation was investigated for levels of inflammatory markers. The study was carried out after seeking permission from Institutional Ethics Committee, Government Medical College, Amritsar. Written informed consent was obtained from the patients. The nature of study was explained to each patient in their vernacular language, and informed consent was taken from all who fulfilled the inclusion criteria and were willing to participate in the study.

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