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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    STUDY OF SERUM ADENOSINE DEAMINASE ACTIVITY IN TYPE 2 DIABETES MELLITUS IN VIDARBHA REGION.


    Dr Yogita Raj Dubey, Sangeeta Dubey Bhargava
    JCDR. 2024: 1480 -1484

    Abstract

    Background: Diabetes mellitus (DM) is one of the most important cause of mortality in India characterized by hyperglycaemia due to deficiency of insulin and insulin resistance . Adenosine deaminase (ADA) is a purine metabolizing enzyme that catalyses the deamination of adenosine to inosine and modulates the insulin activity. Aim: To determine the activity of adenosine deaminase in type 2 diabetic patients. Material & Method: We measured the serum level of Adenosine Deaminase (ADA), and Fasting Plasma Glucose (FPG) in 50 patients with type 2 diabetes and 50 healthy controls. Subjects included in study were known diabetics. Results: The levels of Serum Adenosine Deaminase were highly significant (p<0.001) in study group in comparison to control group. Conclusion: Our study concludes that serum Adenosine Deaminase activity significantly increased in type 2 diabetes mellitus. High ADA activity reduces the glucose uptake into cells; therefore, insulin resistance is related to ADA activity.

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    Volume 15 Issue 11

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