Abstract

Background: ST-elevation myocardial infarction (STEMI) is a severe form of acute coronary syndrome associated with significant morbidity and mortality. Troponin I levels and left ventricular ejection fraction (LVEF) are important markers in STEMI, but their relationship is not fully elucidated. Aims and Objectives: 1. To determine Troponin-I levels in acute STEMI patients. 2. To determine the LVEF in acute STEMI patients and its association with Troponin-I levels. Materials and Methods: This cross-sectional study included 50 patients with first-attack STEMI admitted to Guru Nanak Dev Hospital, Amritsar. Patients underwent clinical examination, ECG, and measurement of Troponin-I levels. LVEF was assessed using 2D echocardiography. Patients were categorized based on LVEF: normal (≥55%), mildly reduced (45-54%), moderately reduced (35-44%), and severely reduced (<35%). Results: The mean age of patients was 56.68 ± 11.11 years, with a male predominance (66%). Hypertension (56%) and diabetes mellitus (22%) were common comorbidities. The mean Troponin-I level was 13.55 ± 9.60 ng/ml, and the mean LVEF was 44.04 ± 6.76%. A strong negative correlation was observed between Troponin-I levels and LVEF (r = -0.829, p < 0.001). Troponin-I levels progressively increased as LVEF decreased across subgroups, with statistically significant differences between most LVEF categories. This relationship supports the use of Troponin-I as a potential predictor of left ventricular function in acute STEMI. Conclusion: The findings suggest that Troponin-I levels could be a valuable tool for early risk stratification and management decisions in STEMI patients.

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