E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil.

Abstract
Background:Neonatal Sepsis is a systemic inflammatory response to infection and/or isolation of bacteria from the blood stream in the first 28 days of life.Thrombocytopenia, defined asplatelet count below 150109/L, is a frequent problem in neonatal intensive care units, confounding the clinical course in 2235% of intensive care admissions.Sepsis is the commonest cause of neonatal mortality; it is responsible for about 30-50% of the total neonatal deaths in developing countries.
Objectives: The aim of this study is to analyze the possible risk factors for neonatal thrombocytopenia, its association with neonatal sepsis and the outcome of neonatal sepsis.
Methods: This is a prospective study conducted on 68 babies in NICU of a tertiary care centre. The babies admitted in the NICU with platelet count below 150109/L were taken into consideration. The study included consent by parents/guardian, data collection by meticulous history taking and clinical examination, appropriate laboratory investigations followed by statistical correlations.
Results:Study was conducted with 68 neonates having platelet countbelow 150109/L. Risk factors of neonatal thrombocytopenia involved maternal factors like pre-eclampsia/ pregnancy induced hypertension, premature rupture of membranes, meconium stained liquor, multiparity as well as fetal factors like low birth weight, prematurity, birth asphyxia etc.There was male predominance (70%) amongst study population.Most of the study population had severe thrombocytopenia (47%) followed by moderate thrombocytopenia (42%) and mild thrombocytopenia (11%). 82.4% of study population survived while death occurred in 17.6%.
Conclusion:The present study concludes thatthere is an association of neonatal thrombocytopenia and sepsis. Thrombocytopenia is an earliest indicator as well as a prognostic marker of neonatal sepsis. Most common etiological factors include PROM, low birth weight, prematurity, maternal GBS colonization, birth asphyxia, PIH, multiple gestation, chorioamnionitis and invasive procedures. Starting of empirical antibiotics becomes the mainstay of the treatment. If managed early and effectively, neonatal sepsis has promising outcomes.

Key words: Early onset sepsis, Late onset sepsis, Neonatal Thrombocytopenia


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Dr. Ravindra S. Sonawane
Articles by Dr. Neha R. Kulkarni
Articles by Dr. Sagar V. Sonawane
Articles by Dr. Akshay N. Patil
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil. IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY. J Cardiovasc. Dis. Res.. 2021; 12(5): 15-21. doi:10.31838/jcdr.2021.12.05.04


Web Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil. IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY. http://www.jcdronline.org/?mno=101347 [Access: July 26, 2021]. doi:10.31838/jcdr.2021.12.05.04


AMA (American Medical Association) Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil. IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY. J Cardiovasc. Dis. Res.. 2021; 12(5): 15-21. doi:10.31838/jcdr.2021.12.05.04



Vancouver/ICMJE Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil. IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY. J Cardiovasc. Dis. Res.. (2021), [cited July 26, 2021]; 12(5): 15-21. doi:10.31838/jcdr.2021.12.05.04



Harvard Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil (2021) IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY. J Cardiovasc. Dis. Res., 12 (5), 15-21. doi:10.31838/jcdr.2021.12.05.04



Turabian Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil. 2021. IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY. Journal of Cardiovascular Disease Research, 12 (5), 15-21. doi:10.31838/jcdr.2021.12.05.04



Chicago Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil. "IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY." Journal of Cardiovascular Disease Research 12 (2021), 15-21. doi:10.31838/jcdr.2021.12.05.04



MLA (The Modern Language Association) Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil. "IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY." Journal of Cardiovascular Disease Research 12.5 (2021), 15-21. Print. doi:10.31838/jcdr.2021.12.05.04



APA (American Psychological Association) Style

Dr. Ravindra S. Sonawane, Dr. Neha R. Kulkarni,Dr. Sagar V. Sonawane,Dr. Akshay N. Patil (2021) IS THROMBOCYTOPENIA A RISK FACTOR FOR SEPSIS IN NEONATES? : A PROSPECTIVE STUDY. Journal of Cardiovascular Disease Research, 12 (5), 15-21. doi:10.31838/jcdr.2021.12.05.04





Most Viewed Articles
  • Effects of right ventricular septal versus apical pacing on plasma natriuretic peptide levels
    nikoo M.H, ghaedian m. m., kafi M., fakhrpour A., Jorat M. V., Pakfetrat M., Ostovan M., Zahra Emkanjoo
    J Cardiovasc. Dis. Res.. 2011; 2(2): 104-109
    » Abstract » doi: 10.4103/0975-3583.83036

  • Massive pericardial effusion as the only manifestation of primary hypothyroidism
    Radheshyam Purkait , Anand Prasad , Ramchandra Bhadra , Arindam Basu
    J Cardiovasc. Dis. Res.. 2013; 4(4): 248-250
    » Abstract » doi: 10.1016/j.jcdr.2014.01.001

  • Impact of light exercises in selective cognitive response andhandballshooting accuracy performance in Mesopotamia handball players
    Ahuda Naji Zaidan, Qusay Mohammed Hamdan, Mohammed Kadhim Saleh, Samer Saadoun Abd El , Rida
    J Cardiovasc. Dis. Res.. 2021; 12(2): 141-145
    » Abstract » doi: 10.31838/jcdr.2021.12.02.18

  • Reduced nitrate level in individuals with hypertension and diabetes
    Shiekh Gazalla Ayub, Taha Ayub, Saquib Naveed Khan, Rubiya Dar, Khurshid Iqbal Andrabi
    J Cardiovasc. Dis. Res.. 2011; 2(3): 172-176
    » Abstract » doi: 10.4103/0975-3583.85264

  • Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians
    Mithun Das, Susil Pal, Arnab Ghosh
    J Cardiovasc. Dis. Res.. 2010; 1(2): 86-91
    » Abstract » doi: 10.4103/0975-3583.64442

  • Most Downloaded
  • Assessment of the Knowledge and Attitude of Male Students towards Smoking Based on Health Belief Model
    Rafat Rezapour-Nasrabad, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Khatereh Rostami, Amin Kiani, Afsaneh Ghasemi
    J Cardiovasc. Dis. Res.. 2020; 11(4): 116-121
    » Abstract » doi: 10.31838/jcdr.2020.11.04.20

  • Diabetic Retinopathy, The Automated of Detection of Retinal Fundus Images with Probabilistic Neural Networks (PNN)
    Elvina Amanda, Marischa Elveny, Rahmad Syah
    J Cardiovasc. Dis. Res.. 2020; 11(4): 302-306
    » Abstract » doi: 10.31838/jcdr.2020.11.04.54

  • Investigation of the Relationship between Social Support and Adherence to Treatment among Elderly Individuals with Type II Diabetes Mellitus
    Afsaneh Ghasemi, Rafat Rezapour-Nasrabad, Leila Nikrouz, Fatemeh Izadi, Atousa Karimi, Fateme Shariati Far, Zahra Khiali
    J Cardiovasc. Dis. Res.. 2020; 11(4): 122-129
    » Abstract » doi: 10.31838/jcdr.2020.11.04.21

  • Cardio-Vascular Disease Classification Using Stacked Segmentation Model and Convolutional Neural Networks
    G. Charlyn Pushpa Latha, S. Sridhar, S. Prithi, T. Anitha
    J Cardiovasc. Dis. Res.. 2020; 11(4): 26-31
    » Abstract » doi: 10.31838/jcdr.2020.11.04.05

  • The Prediction of the Bisoprolol Effectiveness in Patients with Stable Coronary Artery Disease with Post-Infarction Cardiosclerosis
    Svetlana S. Bunova, Ol'ga V. Zamahina, Nikolaj A. Nikolaev, Nina I.Zhernakova, Andrey A.Grishchenko
    J Cardiovasc. Dis. Res.. 2020; 11(4): 105-109
    » Abstract » doi: 10.31838/jcdr.2020.11.04.18

  • Most Cited Articles