E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid.

Abstract
BACKGROUND:
The efficacy of trimetazidine (TMZ) in chronic coronary syndrome has been well demonstrated butdata regarding
TMZ in managing acute myocardial infarction (AMI) remain unclear. So, in our study we aimed to evaluate the role
of TMZ in prevention of coronary no-reflow in STEMI patients undergoing primary Percutaneous Coronary
Intervention.
METHODS:
A Prospective observational open label case control study was conducted on 200 STEMI patients who underwent
PPCI. They were subdivided to 2 groups: Group I (control group): 100 patients who were not treated with TMZ.
Group II (TMZ group): 100 patients who were treated by trimetazidine before and after PPCI for 1 month. All
patients were assessed clinically, angiographically, ECG, Full labs and baseline echocardiography and after 1
month.
RESULTS:
There was a trend towards lower Incidence of coronary no reflow in the TMZ group (13%) as compared to the
control group (18%) however it did not reach statistical significance (P-value= 0.32). TMZ group showed highly
significant resolution of ST segment elevation in ECG after 24 hours as compared to the control group (P
value=0.002). The TMZ group also showed statistically significantly improvement of LV ejection fraction as
compared to the control group at 1 month follow up echocardiography (P-value=0.012).
CONCLUSIONSĖ
Although TMZ showed no significant improvement in TIMI flow in STEMI patients who underwent PPCI, however
it was associated with greater resolution of ST segment elevation on ECG and improvement of LV systolic function
(EF% and GLS by speckle tracking) after 1 month.

Key words: STEMI, Coronary no-reflow, Trimetazidine, GLS.


 
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How to Cite this Article
Pubmed Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid. Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. J Cardiovasc. Dis. Res.. 2021; 12(5): 331-342. doi:10.31838/jcdr.2021.12.05.47


Web Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid. Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. http://www.jcdronline.org/?mno=112341 [Access: August 18, 2021]. doi:10.31838/jcdr.2021.12.05.47


AMA (American Medical Association) Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid. Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. J Cardiovasc. Dis. Res.. 2021; 12(5): 331-342. doi:10.31838/jcdr.2021.12.05.47



Vancouver/ICMJE Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid. Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. J Cardiovasc. Dis. Res.. (2021), [cited August 18, 2021]; 12(5): 331-342. doi:10.31838/jcdr.2021.12.05.47



Harvard Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid (2021) Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. J Cardiovasc. Dis. Res., 12 (5), 331-342. doi:10.31838/jcdr.2021.12.05.47



Turabian Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid. 2021. Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Journal of Cardiovascular Disease Research, 12 (5), 331-342. doi:10.31838/jcdr.2021.12.05.47



Chicago Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid. "Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention." Journal of Cardiovascular Disease Research 12 (2021), 331-342. doi:10.31838/jcdr.2021.12.05.47



MLA (The Modern Language Association) Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid. "Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention." Journal of Cardiovascular Disease Research 12.5 (2021), 331-342. Print. doi:10.31838/jcdr.2021.12.05.47



APA (American Psychological Association) Style

Moheb Morad, Ahmed Abdelrahman Sharafeldin, Haitham Galal, Hazem Khorshid (2021) Role of Trimetazidine in Prevention of Coronary No Reflow in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Journal of Cardiovascular Disease Research, 12 (5), 331-342. doi:10.31838/jcdr.2021.12.05.47





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