E-ISSN 0976-2833 | ISSN 0975-3583
 

Original Research 


Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease

Zunjarrao G. Badade, Yogita Mahendra Shinde, Shibban K. Kaul, Sandeep Rai, Sameer Sudhirchandra Kadam, Shilpa Amardeep Kadam.

Abstract
Introduction:
T2DM and CAD poses major threat worldwide contributing to excessive morbidity and mortality, these co-morbidities synergistically interact with inflammatory mechanisms. Amylin is a fraternal twin of insulin, it has a great potential to fibrillation, aggregate formation, and deposition causes proteotoxicity to the vital organs.
Aim: To find the association of amylin with inflammatory markers in T2DM with CAD subjects.
Methodology: Present cross sectional study conducted on 262 subjects (30-60 years); including T2DM with angiographically diagnosed CAD cases (n=131) and healthy controls (n=131). The diabetic and lipid profile were estimated and Amylin, Insulin, hsCRP, TNF-α, and IL-6 levels assessed by ELISA. Ethical approval & written informed consent were obtained. Subjects with inflammatory disorders were excluded. Data analysed on SPSS-24, the Descriptive Statistics performed for p≤0.05 (95% CI). Association between variables and AUC of ROC were performed.
Results: BSL-F/PP, HbA1c, HOMA-IR, TC, TG, LDL-C, VLDL-C and Non-HDL-C) were significantly raised, whereas QUICKI and HDL-C decreased (p<0.001) in T2DM-CAD compared to control. The elevated level of amylin shows strong positive association with TG and also with raised level of hsCRP, IL-6, and TNF-α in T2DM-CAD (p<0.001), this may due to cytokines released by monocytes/macrophages. Hyperamylinemia could promote amylin deposition in pancreas causing apoptosis of pancreatic β-cells and in heart causes structural and functional changes of cardiac myocytes.
Conclusion: Assessment of amylin with inflammatory cytokines may predict pancreatic as well as cardiac dysfunction and helpful in stratification severity, risk; may provide novel therapeutic target for DM-CAD patients.

Key words: Key words: Hyperamylinemia, Insulin resistance, Proteotoxicity


 
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How to Cite this Article
Pubmed Style

Badade ZG, Shinde YM, Kaul SK, Rai S, Kadam SS, Kadam SA. Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease. . 2021; 12(1): 82-92. doi:10.31838/jcdr.2021.12.01.18


Web Style

Badade ZG, Shinde YM, Kaul SK, Rai S, Kadam SS, Kadam SA. Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease. http://www.jcdronline.org//?mno=24174 [Access: April 26, 2021]. doi:10.31838/jcdr.2021.12.01.18


AMA (American Medical Association) Style

Badade ZG, Shinde YM, Kaul SK, Rai S, Kadam SS, Kadam SA. Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease. . 2021; 12(1): 82-92. doi:10.31838/jcdr.2021.12.01.18



Vancouver/ICMJE Style

Badade ZG, Shinde YM, Kaul SK, Rai S, Kadam SS, Kadam SA. Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease. . (2021), [cited April 26, 2021]; 12(1): 82-92. doi:10.31838/jcdr.2021.12.01.18



Harvard Style

Badade, Z. G., Shinde, . Y. M., Kaul, . S. K., Rai, . S., Kadam, . S. S. & Kadam, . S. A. (2021) Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease. , 12 (1), 82-92. doi:10.31838/jcdr.2021.12.01.18



Turabian Style

Badade, Zunjarrao G., Yogita Mahendra Shinde, Shibban K. Kaul, Sandeep Rai, Sameer Sudhirchandra Kadam, and Shilpa Amardeep Kadam. 2021. Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease. Journal of Cardiovascular Disease Research, 12 (1), 82-92. doi:10.31838/jcdr.2021.12.01.18



Chicago Style

Badade, Zunjarrao G., Yogita Mahendra Shinde, Shibban K. Kaul, Sandeep Rai, Sameer Sudhirchandra Kadam, and Shilpa Amardeep Kadam. "Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease." Journal of Cardiovascular Disease Research 12 (2021), 82-92. doi:10.31838/jcdr.2021.12.01.18



MLA (The Modern Language Association) Style

Badade, Zunjarrao G., Yogita Mahendra Shinde, Shibban K. Kaul, Sandeep Rai, Sameer Sudhirchandra Kadam, and Shilpa Amardeep Kadam. "Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease." Journal of Cardiovascular Disease Research 12.1 (2021), 82-92. Print. doi:10.31838/jcdr.2021.12.01.18



APA (American Psychological Association) Style

Badade, Z. G., Shinde, . Y. M., Kaul, . S. K., Rai, . S., Kadam, . S. S. & Kadam, . S. A. (2021) Association of Amylin Polypeptide and Inflammatory Biomarkers in Diabetic Coronary Artery Disease. Journal of Cardiovascular Disease Research, 12 (1), 82-92. doi:10.31838/jcdr.2021.12.01.18