E-ISSN 0976-2833 | ISSN 0975-3583
 

Research Article 


A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM

Dr. Balaji.K., Dr. Sukanya Mukherjee.

Abstract
The prevalence of congenital hypothyroidism is high in India at 5.7 per 10,000 infants and an incidence rate of 1 in 244 in Kerala state. Neonatal mass screening programs have been largely successful in early diagnosis of congenital hypothyroidism. Both, very young and advanced maternal age are considered at risk for adverse pregnancy outcomes which in turn may be a factor for development of congenital hypothyroidism in neonates. The studies related to the role of maternal age as a risk factor for development of congenital hypothyroidism are minimal. Not much studies are available which analyse the association of adequately treated maternal hypothyroidism on the neonatal thyroid dysgenesis and other causes of neonatal congenital hypothyroidism. The study collected data about the age and thyroid status of 120 mothers of neonates in which n=60 cases were Mothers of the neonates with congenital hypothyroidism (TSH > 15.2 IU/mL) and n=60 controls mothers of euthyroid healthy neonates (TSH ≤ 15.2 IU/mL). Data collected regarding the maternal thyroid status was evaluated in the antenatal period during first trimester and neonatal thyroid status was evaluated at birth from cord blood. All the mothers included in the study with hypothyroidism (both cases and controls) were either already on treatment or were treated appropriately during pregnancy. The mean maternal age in cases (n=60) was 34.8 5.7 years while that in control (n=60) was 25.43 4.3 years. There is a high statistically significant (p<0.0001) increase in maternal age in cases compared to controls. The odds of being ≥35 years were higher in mothers of neonates with congenital hypothyroidism as compared to mothers of normal children with Odds ratio of 5.06; and highly significant P value 0.0001. The odds of mothers of neonates with congenital hypothyroidism having hypothyroidism, compared mothers of euthyroid neonates having hypothyroidism is not statistically significant with Odds ratio of 3.14; with P value 0.06. The risks of acquiring congenital hypothyroidism in neonates increase with advanced maternal age. Neonatal TSH levels are dynamic and are affected by several factors including maternal hypothyroidism. Pre-conceptional consultation and evaluation of thyroid status as well as first trimester universal screening and adequate treatment of maternal hypothyroidism may play an effective role in decreasing the incidence of neonatal congenital hypothyroidism, especially in high risk pregnancies due to advanced maternal age.

Key words: Kerala neonates, advanced maternal age, hypothyroidism in neonates, universal neonatal screening, parental screening, Dyshormonogenesis


 
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How to Cite this Article
Pubmed Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee. A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM. J Cardiovasc. Dis. Res.. 2021; 12(3): 392-398. doi:10.31838/jcdr.2021.12.03.59


Web Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee. A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM. http://www.jcdronline.org/?mno=86829 [Access: June 09, 2021]. doi:10.31838/jcdr.2021.12.03.59


AMA (American Medical Association) Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee. A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM. J Cardiovasc. Dis. Res.. 2021; 12(3): 392-398. doi:10.31838/jcdr.2021.12.03.59



Vancouver/ICMJE Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee. A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM. J Cardiovasc. Dis. Res.. (2021), [cited June 09, 2021]; 12(3): 392-398. doi:10.31838/jcdr.2021.12.03.59



Harvard Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee (2021) A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM. J Cardiovasc. Dis. Res., 12 (3), 392-398. doi:10.31838/jcdr.2021.12.03.59



Turabian Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee. 2021. A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM. Journal of Cardiovascular Disease Research, 12 (3), 392-398. doi:10.31838/jcdr.2021.12.03.59



Chicago Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee. "A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM." Journal of Cardiovascular Disease Research 12 (2021), 392-398. doi:10.31838/jcdr.2021.12.03.59



MLA (The Modern Language Association) Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee. "A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM." Journal of Cardiovascular Disease Research 12.3 (2021), 392-398. Print. doi:10.31838/jcdr.2021.12.03.59



APA (American Psychological Association) Style

Dr. Balaji.K. , Dr. Sukanya Mukherjee (2021) A STUDY OF MATERNAL AGE AND THYROID STATUS AND ITS ASSOCIATION WITH NEONATAL CONGENITAL HYPOTHYROIDISM. Journal of Cardiovascular Disease Research, 12 (3), 392-398. doi:10.31838/jcdr.2021.12.03.59





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