ISSN 0975-3583

Journal of Cardiovascular Disease Research

    “A comparative study of the effect of dexmedetomidine and fentanyl on haemodynamic response in patients undergoing lumbar spine surgery under general anaesthesia - a randomized controlled study”

    Rakesh D R, Jitendra Agrawal, Sourabh Shrivastava, Kushal Raj Patidar, Preeti Goyal
    JCDR. 2023: 1407-1413


    Spinal surgeries represent a challenge to the anaesthesiologist as they are accompanied with many perioperative problems. This study was conducted to assess and to compare the effect of intravenous Dexmedetomidine and Fentanyl on intraoperative and postoperative haemodynamics in patients undergoing lumbar spine surgery under general anaesthesia. AIM: To compare the efficacy of Dexmedetomidine and Fentanyl in terms of haemodynamic changes during lumbar spine surgeries under general anaesthesia. STUDY DESIGN: prospective, double blinded, randomised controlled study. METHODS: Sixty four patients of either sex, aged 25-65 years with ASA I and II admitted for lumbar spine surgery under general anaesthesia were randomized into two groups. Thirty two patients received Dexmedetomidine loading dose of 0.5µg/kg over ten minutes before induction followed by infusion at the rate of 0.25µg/kg/hr throughout the surgery similarly, the remaining thirty two patients received Fentanyl loading dose of 1µg/kg over ten minutes followed by infusion at the rate of 0.5µg/kg/hr. Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressures were noted at baseline , after loading dose of respected drugs, after induction, at intubation and throughout the surgery ,which continued in PACU upto 24hours. STATISTICAL ANALYSIS: Statistical tests used were unpaired t-test and Chi square test. Analyzed statistically by SPSS software version 20.0. RESULTS: Both Fentanyl and Dexmedetomidine attenuated the haemodynamic responses. Dexmedetomidine was more successful in reducing the heart rate and blood pressures following stress response which was statistically significant when compared to Fentanyl(p<0.001) Conclusion: Dexmedetomidine proved to have better haemodynamic stability and more effective in attenuating haemodynamic response following intraoperative infusion when compared to Fentanyl.



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    Volume 14 Issue 5