Abstract

To evaluate the efficacy of duloxetine in different doses in postoperative pain relief in patients undergoing lumbar spine surgery.. MATERIAL AND METHOD: : 60 patients of ASA grade І & ІІ of either sex scheduled for lumbar spine surgery under general anaesthesia were divided into 2 groups (n=30 each) randomly.Group D (n=30) Patients who received a 90 mg duloxetine 1 hour before surgery and another tablet the following morning. Group ‘P’(n=30) Patients who received a placebo tablet 1 hour before surgery and again the following morning. Pulse rate, blood pressure, respiratory rate and severity of pain on NRS scale was noted at 0 hr, 4 hr, 8 hr, 12 hr, 16 hr, 20 hr, 24 hr, 28 hr, 32 hr and 48 hr after surgery. And the presence or absence of adverse effects, such as headache, nausea, vomiting, dizziness, and drowsiness were noted. RESULT: Analysis revealed that time for first analgesic requirement was significantly longer with oral Duloxetine 90 mg than with placebo. Pre-emptive oral Duloxetine 90 mg decreases the severity of pain postoperatively but not significantly as compared to placebo in patients posted for lumbar spine surgery under general anaesthesia. Oral Duloxetine 90 mg had no significant effect on cardiovascular and respiratory parameters. Patients receiving duloxetine had higher incidence of nausea, vomiting. CONCLUSION: that time for first analgesic requirement was significantly longer with oral Duloxetine 90 mg than placebo.

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