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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    “Assessment Of Fatality Ratio In Covid19 Patients With Diabetes And Without Diabetes Mellitus: Comparative Retrospective Study in Waves One and Two of Covid-19


    Dr. Mangala Sirsikar, Dr. Suhas Dhulipala, Dr. Shailaja Alapaty, Dr. Alamelu, Dr. Umalakshmi Annavarapu , Dr. Deepthi Mahendrakar, Dr. Jyothi A Natikar
    JCDR. 2023: 254-263

    Abstract

    An infection with the deadly COVID-19 virus is more likely to occur in people with type 2 diabetes mellitus. The virus itself causes an altered glycemic state by raising insulin resistance and lowering beta cell production. This leads to increased blood sugar levels. Aims: In order to make a comparison between the clinical outcomes of people who have diabetes and those who do not have diabetes in terms of survival, mortality, and fatality rates across various categories of clinical severity in both waves of the COVID-19 study. Methods: A tertiary care hospital served as the location for the execution of this retrospective investigation. The data on a total of 1773 participants were gathered from wave one and wave two of the ofCOVID-19 epidemic among diabetics and those who did not have diabetes. Results: In the first wave of the study, there were 1283 individuals who did not have diabetes, but 224 patients (14.9%) did have diabetes. During the second wave, there were 205 individuals, of whom 77 people did not have diabetes and 61 persons did have diabetes.During the first wave of the study, there were no verified fatalities among the non-diabetic participants who made up 1283 of the subjects who survived. Out of the diabetics, 199 (88.8%) made it through, while 25 (11.16%) did not. The number of non-diabetics who survived wave two was 192 (94%), whereas the number of diabetics who survived was 52 (81.88%). The death rate was determined to be 13 (6.34%) among non-diabetic individuals and 9 (14.75%) among diabetic individuals, respectively. First wave diabetes had a Case Fatality Rate (CFR) of 11.16 percent. The CFR was 14.75 percent in diabetics and 4.33 percent in non-diabetics, according to the second round of studies. Conclusion: The CFR was found to be high in both waves in diabetics, which suggests that increased glycated hemoglobin and poor blood sugar management both enhance the chance of severity. In wave two, the CFR indicated that non-diabetics were experiencing an enhanced cytokine storm.

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