Abstract

The diagnosis of prostate cancer (PC) is based on a mix of architectural, cytological, and ancillary aspects, none of which is completely sensitive and specific. Present study aimed to study the AMACR in differentiating the prostate malignancy from benign and its mimickers. Material & Method: The present cross-sectional study was conducted among 40 cases for period of 2years from Nov 2016 to May 2018 at department of Pathology, Bangalore Medical College, Bengaluru. It included the include 40 prostate biopsies/transurethral resection of prostate (TURP) specimens/prostatectomies received from the Department of Urology. All the specimens obtained were fixed in buffered neutral formalin and stained for H& E and histopathological evaluation, AMACR cellular localisation, as granular and cytoplasmic, positive control is of prostate cancer. Result: Total of 40 prostate samples, with 13 cases showing benign and malignant lesions and 14 cases with premalignant lesions. AMACR showed 100% sensitive in malignant cases and specificity of AMACR is 14.29% in differentiating malignant and premalignant cases. AMACR is 100% sensitive and specific in differentiating benign and malignant prostatic lesions. Conclusion: Concluded that AMACR is of great value in differentiating HGPIN and malignant glands from benign glands.

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