Abstract

Evalution of analgesic activity of methanolic extract of sida acuta on rats using by eddy’s hot plate. Pain was induced in Wistar albino rats by all Formulations for analgesic activity were administered orally aqueous diclofenac sodium. The dose was set to 10mg/kg body weight. For the assessment of analgesic activity the animals divided into four groups each composed of five animals. All groups received intraperitoneal injection (maximum 1 ml as per ethical norms). Leafs of sida acuata plant were collected, dried the flowers.Dried materials were taken, crushed it to coarse powder.The materials were weighed and transfer in to a clean round bottom flask.Sufficient quantity of methanol was added till it totally immersed and maceration it for seven days.The extract was filtered by using muslin cloth.The obtain filtrate was evaporated and cooled to dryness at 450 to 550c. Until it become like a semisolid.Animals were divided into four groups.Normal control group was treated with saline,test group was treated with extract low dose 100 mg/kg and extract at high dose 200 mg /kg and as standard treated with diclofenac sodium (9 mg/kg). The reaction time was recorded before (0 min) and at 15, 30, 45, and 60 min after the administration of the treatments. The maximum reaction time was fixed at 45 sec to prevent any injury to the tissues of the paws. If the reading exceeds 45 sec, it would be considered as maximum analgesia. The present study showed that the pain relief in test group where it was compared with the positive standard group.It showed the analgesic activity

Description