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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    “LIPOPROTEIN-A LEVEL AS A RISK FACTOR IN PATIENTS WITH ACUTE CORONARY SYNDROME” - A CASE SERIES


    Patel Jigar , Kothi Zuber, Parikh Udit
    JCDR. 2023: 846-853

    Abstract

    Lipoprotein(a) [Lp(a)] is an atherogenic particle that structurally resembles low density lipoprotein [LDL] but contains a molecule of apo-lipoprotein(a). Elevated plasma concentrations of Lp(a) have been shown to be one of the independent risk factors for atherosclerosis. Lp(a) levels have been found to be associated with stable CAD, ACS and with severity of ACS. Lp(a) was first described in human plasma by Norwegian genetic scientist Karen Berg in 1963. By mid 1980s, it was recognised as an independent genetically determined risk factor for premature CAD. In earlier studies, it was highlighted as an independent risk factor for premature CAD in absence of other risk factors. Recent studies have highlighted the potent role of Lipoprotein (a) in accentuating positive risk associated with all conventional and emerging risk factors. Lp (a) excess increases risk of premature CAD, depending on the absence or presence of concomitant risk factors. (1) Lp(a) levels in human samples are mainly measured using immunoassays with polyclonal antibodies against apoA.

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    Volume 14 Issue 6

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