Abstract

BACKGROUND: Psoriasis is a group of common, chronic, inflammatory and proliferative conditions of the skin, associated with systemic manifestations in many organ systems. AIM: To assess the role of serum adenosine deaminase activity in predicting disease severity in psoriasis patients. MATERIAL & METHODS: This was a hospital based cross-sectional study carried out in the Department of Biochemistry, at Assam Medical College & Hospital, Dibrugarh, Assam, India for a period of 12 months i.e,1stApril 2023 to 31st March 2024. The total sample size was 80 which include all newly diagnosed cases of psoriasis attended OPD and IPD of the hospital. The severity of the disease was scored according to Psoriasis Area and Severity Index (PASI). RESULTS: Out of the total 80 blood samples collected from the psoriasis patients, maximum number of patients were observed from the age group of 30-49(63.75%) and least were found in theage group of 50-60 (15%). The frequency of maleswas higher than that of females, 70% and 30% respectively. Linear regression showed that Serum ADA activity has a positive correlation with disease severity (r=0.9783) and statistically significant (p<0.0001). CONCLUSION: In the present study, we concluded that for the purpose of anticipating the severity of psoriasis and monitoring the effectiveness of treatment, serum adenosine deaminase activity can be suggested as a potentially useful biomarker.

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