Abstract

It has been found in many studies that elevated UA is a risk factor for the development of cardiovascular disease. It is unknown whether UA independently predicts target organ damage in patients with hypertension. In view of this, we undertook the present study to evaluate the association of serum uric acid level with target organ damage in essential hypertension. Present study was cross sectional in nature conducted on 66 essential hypertensive patients. All patients fulfilling inclusion criteria and exclusion criteria were taken up for the study. Majority of the patients was in the age group of 40-60 years and most of them were male. Out of total 66 hypertensive patients, majority, 28 (42.42%) did not have any target organ damage followed by 22 (33.33%) cases had one organ damage and 16 (24.24%) had two organ damage. Of the 38 cases having damaged organ; 12 (31.57%) was having left ventricular hypertrophy, 10 (26.32%) was having micro albuminuria and 16 (42.11%) was having both, LVH as well as micro albuminuria. Mean SUA was 7.98 + 3.9 mg/L, 6.79 +2.77 mg/L and 5.67 + 1.88 mg/L among cases with two, one and no organ damage respectively, which differed significantly between these three groups (p=0.002). Increased serum uric acid level (SUA) was significantly associated with number of organ damaged and severity of hypertension

Description

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