Abstract

INTROUCTION: Spinal anesthesia (SA) has become a popular technique for LSCS as it is advantageous being a quick, safe and a reliable option that also provides analgesia post-operatively. Hyperbaric drugs which are routinely used can produce very high blocks in pregnant women because of decreased volume and increased pressure of CSF due to engorged epidural veins which is a result of aorto-caval compression and high CSF pressure. Haemodynamic changes1,2,3 like hypotension, Bradycardia were commonly associated complication with spinal-anaesthesia in obstetric parturients. For minimizing spinal-induced haemodynamic changes with anticholinergic drugs may be of interest. Anticholinergics like atropine and Glycopyrrolate are routinely used in anaesthesia for premedication. Atropine easily crosses placental barrier and blood-brain barrier as it has a tertiary amine structure. However, Glycopyrrolate having a structure of quaternary amine, limits its ability to cross these barriers. Hence Glycopyrrolate is the desired option for obstetric parturients

Description